Lichen simplex chronicus is a condition where repeated scratching or rubbing of a site creates a localized, itchy, thickened, leathery patch of skin. Lichen simplex chronicus can present as a solitary lesion or as multiple lesions—usually in areas that are easy to reach. The most commonly involved sites include the scalp and neck, groin (scrotum or vulva), forearms, shins, or ankles. The condition most commonly affects women between the ages of 30 and 50. It can occur in individuals without other medical or skin problems. However, it can also occur in patients with underlying psychiatric conditions (anxiety), itchy skin conditions (eczema), or other systemic diseases associated with itching. Treatment involves breaking the itch-scratch cycle. Antihistamines, topical medications, and intralesional steroid injections are commonly used therapies.