Fillers (examples: Belotero, Juvederm, Radiesse, Restylane, Sculptra, Voluma) are injectable treatments that help diminish the signs of aging. Fillers are composed of soft, gel-like substances that can either be synthetic or naturally occurring in nature. They can be temporary (absorbable) or permanent (non-absorbable). Fillers are commonly used to plump up lips, restore volume and fullness to the face, smooth out the appearance of fine lines and wrinkles, fill in depressed scars, or to rejuvenate hands.